In developing and self-renewing tissues, differentiated cell types are typically specified through the actions of multistage cell lineages. Such lineages commonly include a stem cell and multiple progenitor (transit amplifying; TA) cell stages, which ultimately give rise to terminally differentiated (TD) cells. Typically, as the tissue reaches a tightly controlled steady-state size, the cells at different lineage stages also assume distinct spatial locations within the tissue. Although significant genetic information are revealed on locations of different type of cells, the underlining mechanisms that cause the spatial heterogeneity and precise tissue size control are not yet completely understood. In this talk, I will present modeling and simulations to explore several plausible strategies that can be utilized to create stratification and achieve size control during development or regeneration of olfactory epithelium (OE) in mouse.